BACTERIAL EFFLUX PUMP INHIBITORS

摘要

Disclosed herein are compounds of formula I:;;and salts thereof. Also disclosed are compositions comprising of compounds of formula I and methods using compounds of formula I.

主权项

1. A compound of formula I: R1 is (C3-C8)alkyl substituted with two or more groups selected from —NRb1Rc1, —NHNH2, —C(═NRa1)(NRb1Rc1), —NRa1C(═NRa1)(Rd1) and —NRa1C(═NRa1)(NRb1Rc1); R2 is hydrogen or (C1-C3)alkyl; each R3 is independently hydrogen, halo or (C1-C4)alkyl; R4 is aryl, heteroaryl, aryl(C1-C6)alkyl- or heteroaryl(C1-C6)alkyl- wherein any aryl, heteroaryl, aryl(C1-C6)alkyl- or heteroaryl(C1-C6)alkyl- of R4 is optionally substituted with one or more groups independently selected from halo, (C1-C4)alkyl, (C1-C4)haloalkyl, (C1-C4)alkoxy and (C1-C4)haloalkoxy; R5 is hydrogen, (C1-C3)alkyl, aryl, heteroaryl, aryl(C1-C6)alkyl- or heteroaryl(C1-C6)alkyl- wherein any aryl, heteroaryl, aryl(C1-C6)alkyl- or heteroaryl(C1-C6)alkyl- of R5 is optionally substituted with one or more groups independently selected from halo, (C1-C4)alkyl, (C1-C4)haloalkyl, (C1-C4)alkoxy and (C1-C4)haloalkoxy, provided that when R5 is hydrogen or (C1-C3)alkyl, and R4 is optionally substituted phenyl, then n is not 0; each Ra1 is independently hydrogen or (C1-C4)alkyl; each Rb1 and Rc1 is independently hydrogen or (C1-C4)alkyl; Rd1 is (C1-C3)alkyl and n is 0 or 1; or a salt thereof.