发明名称 |
Polymorphic forms of the sodium salt of 4-tert-butyl-N-[4-chloro-2-(1-oxy-pyridine-4-carbonyl)-phenyl]-benzenesulfonamide |
摘要 |
Disclosed are novel novel polymorphic solvated and desolvated forms of the sodium salt of 4-tert-butyl-N-[chloro-2-(1-oxy-pyridine-4-carbonyl)phenyl]-benzenesulfonamide. One embodiment of the present invention is directed to a crystalline sodium salt of 4-tert-butyl-N-[4-chloro-2-(1-oxy-pyridine-4-carbonyl)-phenyl]benzenesulfonamide (hereinafter “Compound A-1,4-dioxane/water solvate”), wherein the crystalline form is characterized by an X-ray powder diffraction pattern comprising diffraction angles (° 28), when measured using Cu Ku radiation, at about 4.0, 8.1, 10.1, 14.2, 16.2, 18.6, 20.3, 24.7, 25.0, and 26.5. |
申请公布号 |
US9493417(B2) |
申请公布日期 |
2016.11.15 |
申请号 |
US201514832755 |
申请日期 |
2015.08.21 |
申请人 |
ChemoCentryx, Inc. |
发明人 |
Bis Joanna;Igo David H. |
分类号 |
C07D211/70;C07D213/89;A61K31/4425;A61K45/06 |
主分类号 |
C07D211/70 |
代理机构 |
Brinks Gilson & Lione |
代理人 |
Brinks Gilson & Lione ;Marshall Ryan L. |
主权项 |
1. A crystalline form of a sodium salt of 4-tert-butyl-N-[4-chloro-2-(1-oxy-pyridine-4-carbonyl)-phenyl]-benzenesulfonamide, wherein the crystalline form is characterized by an X-ray powder diffraction pattern containing diffraction angles, when measured using Cu Kα radiation, at about 5.9, 16.1, 17.4, 18.0, 20.4, and 23.7° 2θ. |
地址 |
Mountain View CA US |