Compositions and Methods for Increasing the Metabolic Lifetime of Dextromethorphan and Related Pharmacodynamic Effects

摘要

This disclosure relates to methods administering various compounds in conjunction with dextromethorphan to a human being. Dosage forms, drug delivery systems, and methods related to dextromethorphan or dextrorphan and bupropion, hydroxybupropion, erythrohydroxybupropion, threohydroxybupropion, or a metabolite or prodrug of any of these compounds are also disclosed

主权项

1. A method of correcting extensive metabolism of the dextromethorphan in a human subject in need thereof, comprising co-administering to the human subject once a day for at least eight consecutive days or twice a day for at least eight consecutive days:
1) a hydroxybupropion, a threohydroxybupropion, a erythrohydroxybupropion or a bupropion; and 2) a dextromethorphan;wherein the daily dose of the dextromethorphan is about 40 mg to about 350 mg, and co-administration of the hydroxybupropion, the threohydroxybupropion, the erythrohydroxybupropion or the bupropion, and the dextromethorphan results in a first AUC0-24 of the dextromethorphan that is at least about 50 ng·hr/mL, and the first AUC0-24 of the dextromethorphan is at least about 20 times a second AUC0-24 of the dextromethorphan that would result from administering the daily dose of the dextromethorphan without the hydroxybupropion, the threohydroxybupropion, the erythrohydroxybupropion or the bupropion to the human subject.