Device for controlled release of active agent in the stomach

摘要

A device with delayed pylorus passage, for the controlled release of active agents (A) in the gastro-intestinal tract, comprises a component (2) which expands on contact with gastric juice (2), surrounded by a membrane (1) which is permeably to gastric juice and to (A). The novelty is that (A) is present in a multi-particulate preparation (3) providing retarded release of (A).The device preferably expands by production of carbon dioxide gas from bicarbonates