Methods for treating cancer using anti-PD-1 antibodies in combination with anti-CTLA-4 antibodies

摘要

The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.

主权项

1. A method of inhibiting tumor growth in a subject having a tumor that does not express PD-L1 comprising administering to the subject a combination of a dose of an anti-PD-1 monoclonal antibody or an antigen-binding portion thereof and a dose of an anti-CTLA-4 monoclonal antibody or an antigen-binding portion thereof, wherein the combination of the anti-PD-1 antibody or antigen-binding portion thereof and the anti-CTLA-4 antibody or antigen-binding portion thereof inhibits growth of the tumor in the subject.