Methods and materials for stabilizing analyte sensors

摘要

The disclosure provides a sensor including a sensor having an external surface and a cannula. The cannula comprises a substantially cylindrical wall encircling a lumen, at least one aperture and a distal end. The sensor is positioned within the lumen and the distal end of the cannula extends beyond the sensor. This configuration functions for example to stabilize chemical reactions associated with the sensor by creating a buffer zone between the sensor and the surrounding tissues at the site of implantation. In certain embodiments, the sensor can further comprise an accessory material in proximity to the external surface, wherein the accessory material modifies the biological response of a tissue that is in contact with the sensor. The sensor can also comprise anchors that keeps the sensor in contact with subcutaneous tissue of a subject upon insertion of the sensor into the body of the subject.

主权项

1. A sensor system comprising:
a sensor having a chemically reactive surface that reacts with an analyte to be sensed; and a cannula comprising: a substantially cylindrical housing that surrounds the sensor; at least one aperture disposed in the housing that allows the analyte to diffuse therethrough so as to contact the chemically reactive surface; an end that extends beyond an end of the sensor; an accessory material provided in proximity to the chemically reactive surface, wherein: the accessory material fills the at least one aperture of the cannula; the accessory material is disposed in the aperture such that a surface of the accessory material is substantially flush with a surface of the cannula; and the sensor system is adapted to contact a tissue such that the accessory material is configured to contact and modify a biological response of the tissue.