| 主权项 |
1. A compound of the formula: or a pharmaceutically acceptable salt thereof, wherein R1 is one of the formulas: wherein
n is 0;each R7 is independently halogen, cyano, nitro, C1-6 alkyl, C1-6 haloalkyl, —OR10, —SR10, —N(R10)2, —C(O)R10, —C(O)OR10, —C(O)N(R10)2, —S(O)2R10, —OC(O)R10, —OC(O)OR10, —OC(O)N(R10)2, —N(R10)C(O)R10, —N(R10)C(O)OR10, or —N(R10)C(O)N(R10)2, wherein each R10 is independently hydrogen or C1-6 alkyl;R8 is halogen, cyano, nitro, C1-6 alkyl, C1-6 haloalkyl, or -Q-R8′;Q is —O—, —S—, —NH—, or —N(C1-6 alkyl)-;R8′ is hydrogen, C1-6 alkyl, C2-6 alkenyl, C1-6 haloalkyl, C3-8 cycloalkyl, heterocyclyl, aryl, arylC1-6 alkyl, heteroaryl, or heteroarylC1-6 alkyl, wherein the alkyl, aryl, arylalkyl, heteroaryl, and heteroarylalkyl are optionally substituted with one, two, three, or four groups that are each independently halogen, cyano, nitro, C1-6 alkyl, C1-6 haloalkyl, —OR14, —SR14, —N(R14)2, —C(O)R14, —C(O)OR14, —C(O)N(R14)2, —S(O)2R14, —OC(O)R14, —OC(O)OR14, —OC(O)N(R14)2, —N(R14)C(O)R14, —N(R14)C(O)OR14, or —N(R14)C(O)N(R14)2, wherein each R14 is independently hydrogen or C1-6 alkyl; andeach R9 is independently hydrogen or C1-6 alkyl; R2 is hydrogen, C1-6 alkyl, C1-6 haloalkyl, —C1-4 alkyl-R12, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, monocyclic heterocyclyl, monocyclic heteroaryl, or phenyl, wherein the alkyl, cycloalkyl, heterocyclyl, heteroaryl, and phenyl groups are each optionally substituted with one or two R13 groups;
each R13 is independently C1-6 alkyl, C1-6 haloalkyl, —OR, —SR, —NR2, —C(O)R, —C(O)OR, —C(O)NR2, —S(O)2NR2, or —S(O)2R; andwhere R12 is —OR, —SR, —NR2, —C(O)R, —C(O)OR, —C(O)NR2, —S(O)2R, —OC(O)R, —OC(O)OR, —OC(O)NR2, —N(R)C(O)R, —N(R)C(O)OR, —N(R)C(O)NR2, phenyl, monocyclic heteroaryl, C3-8 cycloalkyl, or monocyclic heterocyclyl, wherein the aryl, heteroaryl, C3-8 cycloalkyl, and heterocyclyl groups are each optionally substituted by one, two, or three groups that are each independently halogen, cyano, nitro, C1-6 alkyl, C1-6 haloalkyl, —OR, —SR, —NR2, —C(O)R, —C(O)OR, —C(O)NR2, —S(O)2R, —OC(O)R, —OC(O)OR, —OC(O)NR2, —N(R)C(O)R, —N(R)C(O)OR, or —N(R)C(O)NR2;
and each R is independently hydrogen, C1-6 alkyl, C2-6 alkenyl, C1-6 haloalkyl, C3-8 cycloalkyl, heterocyclyl, aryl, arylC1-6 alkyl, heteroaryl, or heteroarylC1-6 alkyl, wherein the alkyl, aryl, arylalkyl, heteroaryl, and heteroarylalkyl are optionally substituted with one, two, three, or four groups that are each independently halogen, cyano, nitro, C1-6 alkyl, C1-6 haloalkyl, —OR0, —SR0, —N(R0)2, —C(O)R0, —C(O)OR0, —C(O)N(R0)2, —S(O)2R0, —OC(O)R0, —OC(O)OR0, —OC(O)N(R0)2, —N(R0)C(O)R0, —N(R0)C(O)OR0, or —N(R0)C(O)N(R0)2, wherein each R0 is independently hydrogen or C1-6 alkyl;or R2 and R3 together with the atoms to which they are attached form 2-oxo-2,3-dihydro-imidazolyl ring; R3 and R4 are independently hydrogen; and R5 and R6 are independently hydrogen. |
