| 摘要 |
The present invention relates to a biocompatible and thermosensitive poly(ethylene glycol)/polyester block copolymer and a method of its preparation thereof, and particularly to a multi-functional intelligent hydrogel polymer comprising a hydrophilic part of a poly(ethylene glycol) (PEG) having a low molecular weight and a hydrophobic part comprising an ester-based caprolactone (CL) segment as an essential ingredient and further comprising a para-dioxanone (PDO) segment, a trimethylene carbonate (TMC) segment or a PDO/TMC copolymer containing the PDO and the TMC segments in a predetermined ratio, which easily forms a desired-shaped gel and decomposes or disperses without necessitating the operation process for removing the gel due to the temperature-dependent phase transition caused by the coagulation and the expansion of polymer micelles comprising a hydrophilic part and a hydrophobic part, thus being applicable to a drug delivery system or a porous support for tissue engineering purpose.
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