发明名称 |
HIGH AFFINITY ANTIBODIES TO HUMAN IL-6 RECEPTOR |
摘要 |
A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a KD of about 500 pM or less and blocks IL-6 activity with an IC50 of 200 pM or less, is provided. In preferred embodiments, the antibody the antibody or antigen-binding fragment binds hIL-6R with an affinity at least 2-fold higher relative to its binding monkey IL-6R. |
申请公布号 |
US2016229916(A1) |
申请公布日期 |
2016.08.11 |
申请号 |
US201615136152 |
申请日期 |
2016.04.22 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
STEVENS Sean;HUANG Tammy T.;MARTIN Joel H.;FAIRHURST Jeanette L.;RAFIQUE Ashique;SMITH Eric;POBURSKY Kevin J.;PAPADOPOULOS Nicholas J.;FANDL James P.;CHEN Gang;KAROW Margaret |
分类号 |
C07K16/28 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Tarrytown NY US |