发明名称 |
Compositions and methods for silencing apolipoprotein C-III expression |
摘要 |
The present invention provides compositions comprising therapeutic nucleic acids such as interfering RNA that target apolipoprotein C-III (APOC3) gene expression, lipid particles comprising one or more (e.g., a cocktail) of the therapeutic nucleic acids, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles (e.g., for the treatment of lipid diseases or disorders such as atherosclerosis or a dyslipidemia such as hypertriglyceridemia or hypercholesterolemia). |
申请公布号 |
US9428751(B2) |
申请公布日期 |
2016.08.30 |
申请号 |
US201514676489 |
申请日期 |
2015.04.01 |
申请人 |
Protiva Biotherapeutics, Inc. |
发明人 |
MacDonald Marcia;Lee Amy C. H.;MacLachlan Ian |
分类号 |
A61K48/00;C07H21/02;C07H21/04;C12N15/11;C12N15/113;A61K47/48;A61K9/127;A61K9/16;A61K31/713;B82Y5/00 |
主分类号 |
A61K48/00 |
代理机构 |
Viksnins Harris & Padys PLLP |
代理人 |
Viksnins Harris & Padys PLLP |
主权项 |
1. A composition comprising a small-interfering RNA (siRNA) that silences apolipoprotein C-III (APOC3) gene expression, wherein the siRNA comprises a sense strand and a complementary antisense strand, and wherein the siRNA comprises a double-stranded region of about 19 to about 25 nucleotides in length, and wherein the antisense strand comprises a sequence set forth in SEQ ID NO:770 and/or wherein the sense strand comprises a sequence set forth in SEQ ID NO:769. |
地址 |
Burnaby, BC CA |