发明名称 |
Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
摘要 |
Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity. |
申请公布号 |
US9428464(B2) |
申请公布日期 |
2016.08.30 |
申请号 |
US201214241699 |
申请日期 |
2012.08.28 |
申请人 |
CHDI Foundation, Inc. |
发明人 |
Courtney Stephen Martin;Prime Michael;Mitchell William;Brown Christopher John;De Aguiar Pena Paula C.;Johnson Peter;Dominguez Celia;Toledo-Sherman Leticia M.;Muñoz-Sanjuan Ignacio |
分类号 |
C07D239/52;A61K31/506;C07D239/28;C07D403/12;C07D403/06;C07D405/12;C07D413/12;C07D491/048;C07D239/42;C07D401/04;C07D401/12;C07D417/12;C07D471/04;C07D487/04 |
主分类号 |
C07D239/52 |
代理机构 |
Sheppard Mullin Richter & Hampton LLP |
代理人 |
Sheppard Mullin Richter & Hampton LLP |
主权项 |
1. A compound selected from the group consisting of:
6-Naphthalen-2-yl-pyrimidine-4-carboxylic acid; and 6-Biphenyl-3-yl-pyrimidine-4-carboxylic acid; or a pharmaceutically acceptable salt thereof. |
地址 |
New York NY US |