Compositions comprising CB receptor agonists, uses thereof and methods for their preparation

摘要

Provided are compositions including (3R, 4R, 6R)-stereoisomers of phenyl substituted pinenes having CB receptor agonist properties, methods of treating diseases or disorders with the pharmaceutical compositions, and processes for their preparation are also provided.

主权项

1. A composition comprising the (3R, 4R, 6R)-diastereomer of a compound of general formula (II): wherein is a double bond; R1 is independently selected from —R2OR3, —C(═O)R4, and —OC(═O)R5; R2 is a C1-C5 straight or branched alkylene; R3 is selected from the group consisting of H, —C(═O)OH, straight or branched C1-C5 alkyl, straight or branched C1-C5 acyl, and straight or branched C1-C5 amide; R4, and R5 are independently selected from the group consisting of H, OH, straight or branched C1-C5 alkyl, straight or branched C1-C5alkoxy, and straight or branched C1-C5 amine; R6 and R7 are each independently selected from H, and —OR8 wherein R8 is a straight or branched C1-C5 alkyl, provided that at least one of R6 and R7 is different than H; and R9 is independently selected from an optionally substituted straight or branched C6-C12 alkyl, an optionally substituted straight or branched C5-C9 alkoxy, and an optionally substituted straight or branched C1-C7 ether.