发明名称 |
SEPARATION OF ENANTIOMERS OF 3-ETHYLBICYCLO[3.2.0]HEPT-3-EN-6-ONE |
摘要 |
A process to isolate a compound of Formula (2a) or a salt or solvate thereof, comprising a) reacting a mixture of diastereoisomers of Formulae (2a, 2b) with a basic heterocyclic-aldehyde compound and an optically active amine in the presence of a base; and b) separating the compound of Formula (2a) from the product of step a) by acid extraction. The compound of Formula (2a) may be produced with an enantiomeric excess of 98%. Compounds of Formula (2a) are useful intermediates in a process to prepare a bicyclic γ - amino tetrazole derivative of Formula (I) which finds utility in treating neuropathic pain and disorders of the central nervous system. |
申请公布号 |
WO2016146299(A1) |
申请公布日期 |
2016.09.22 |
申请号 |
WO2016EP52176 |
申请日期 |
2016.02.02 |
申请人 |
NOVASSAY SA |
发明人 |
FORD, Rhonan Lee;MEGHANI, Premji |
分类号 |
C07D257/04;C07B57/00;C07C49/627 |
主分类号 |
C07D257/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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