Asparaginsyrederivater

摘要

The present invention is directed to derivatives of aspartic acid with a new type of side-chain protecting group. The present invention is further directed to methods of their preparation and their use in Fmoc based solid phase peptide synthesis as well as the Z/tBu based solution synthesis of peptides. The use of the aspartic acid derivatives according to the present invention leads to the minimization of base catalyzed aspartimide formation during peptide synthesis and supports the prevention of aspartimide derived impurities.