发明名称 |
NOVEL COMPOUNDS POSSESSING ANTIBACTERIAL, ANTIFUNGAL OR ANTITUMOR ACTIVITY |
摘要 |
The present invention provides novel compounds possessing one or more of the following activities: antibacterial, antifungal and antitumor activity. The compounds are of Formula (I): wherein: Z1 and Z2 are independently-NR3- (wherein R3 is hydrogen or alkyl) or -O-; R1 and R2 are independently substituted alkyl, substituted aryl, heteroaryl, or substituted heteroaryl provided that at least one of R1 and R2 is a group that can form a pharmaceutically acceptable acid addition salt; R3 is hydrogen, alkyl or R3 and R1 or R2 together with the atoms to which they are attached form a heterocyclic ring; X2 is aryl, substituted aryl, heteroaryl, substituded heteroaryl, alkenyl, alkynyl, cycloalkyl or heterocyclic; X1 and X3 are independently aryl, substituted aryl, heteroaryl, substituted heteroaryl, or - CHR4, wherein R4 is natural or unnatural amino acid side chain; or a pharmaceutically acceptable acid addition salt thereof.Pharmaceutical compositions containing these compounds, methods of making and methods for using these compounds are also provided.
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申请公布号 |
CA2414512(A1) |
申请公布日期 |
2002.01.03 |
申请号 |
CA20012414512 |
申请日期 |
2001.06.26 |
申请人 |
GENELABS TECHNOLOGIES, INC. |
发明人 |
MUCHOWSKI, JOSEPH MARTIN;NELSON, PETER HAROLD;ROBERTS, CHRISTOPHER DON;ZHANG, WENTAO;LIEHR, SEBASTIAN JOHANNES R.;VELLIGAN, MARK DOUGLAS;BOTYANSZKI, JANOS;KHORLIN, ALEXANDER;SHI, DONG-FANG;DYATKINA, NATALIA B. |
分类号 |
A61K31/395;A61K31/40;A61K31/404;A61K31/4439;A61K31/496;A61K31/506;A61P31/00;A61P31/04;A61P31/10;A61P35/00;A61P43/00;C07D207/34;C07D209/42;C07D209/88;C07D401/14;C07D403/14;C07D409/14;(IPC1-7):C07D403/14 |
主分类号 |
A61K31/395 |
代理机构 |
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