发明名称 |
Antibodies to bacterial stress proteins |
摘要 |
The present invention relates to antibodies to a purified stress protein of 86 Kd and fragments thereof isolated from the genus Corynebacterium. Particular fragments include those with apparent molecular weights of 50 Kd and 52 Kd. The stress protein has been found to be an immunodominant conserved antigen. Patients with Corynebacterium jeikeium septicemia or endocarditis have antibody to the 52 Kd breakdown product. The protein cross-reacts with a peptide antigen KVIRKNIVKKMIE using a mouse monoclonal antibody against the peptide. The antibodies are useful for diagnosis and treatement of Corynebacterium infections and diseases.
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申请公布号 |
US5985277(A) |
申请公布日期 |
1999.11.16 |
申请号 |
US19970878844 |
申请日期 |
1997.06.19 |
申请人 |
THE VICTORIA UNIVERSITY OF MANCHESTER |
发明人 |
BURNIE, PETER JAMES |
分类号 |
A61K38/00;A61K39/00;A61K39/05;A61K39/395;A61P31/04;C07K14/00;C07K14/195;C07K14/34;C07K14/41;C07K16/00;C07K16/12;C12N5/10;C12N15/02;C12P21/02;C12P21/08;C12R1/15;C12R1/91;G01N33/53;G01N33/569;(IPC1-7):A61K39/395;A61K39/40;C07H21/04 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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