发明名称 |
REVERSE GENETICS OF NEGATIVE-STRAND RNA VIRUSES IN YEAST |
摘要 |
The present invention relates to a methodology for the generation of infectious ribonucleoparticles (RNPs) of negative-strand RNA viruses, and in particular of non-segmented negative-strand RNA viruses in yeast, especially in budding yeast. Accordingly, the patent application relates to a recombinant yeast strain suitable for the rescue of infectious non-segmented negative-strand RNA virus particles or infectious virus-like particles. The invention also relates to the use of the recombinant yeast to prepare vaccine seed and to the use of the produced RNPs or RNPs-like to prepare vaccine formulations. It also concerns the use of the recombinant yeast for the screening of libraries of DNA. |
申请公布号 |
EP2561081(B1) |
申请公布日期 |
2016.12.28 |
申请号 |
EP20090707059 |
申请日期 |
2009.01.30 |
申请人 |
Institut Pasteur;Centre National de la Recherche Scientifique |
发明人 |
MILED, Chaouki;TANGY, Frédéric;JACOB, Yves |
分类号 |
A61K39/165;A61K39/00;A61K39/12;C07K14/005;C12N7/00;C12N15/81 |
主分类号 |
A61K39/165 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|