| 发明名称 | Fusion molecules and IL-15 variants | ||
| 摘要 | The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the such proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention. | ||
| 申请公布号 | US9464127(B2) | 申请公布日期 | 2016.10.11 |
| 申请号 | US201313946438 | 申请日期 | 2013.07.19 |
| 申请人 | Altor Bioscience Corporation | 发明人 | Wong Hing C.;Rhode Peter;Zhu Xiaoyun;Han Kai-ping |
| 分类号 | C07K14/54;C07K14/705;C07K19/00;C07K16/18;C12N15/62;C12N15/09;C07K14/715;A61K47/48;C07K14/725;C07K16/28;G01N33/569;C07K14/435;C07K14/47;C07K16/24;C12N15/24;A61K38/00;C12P21/00;A61K38/20 | 主分类号 | C07K14/54 |
| 代理机构 | Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. | 代理人 | Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. ;Corless, Esq. Peter F.;Clarke Daniel W. |
| 主权项 | 1. A soluble fusion protein complex comprising at least two soluble fusion proteins, wherein the first fusion protein comprises (a) a first antibody covalently linked to (b) interleukin-15 (IL-15) polypeptide; and the second fusion protein comprises (c) a second antibody covalently linked to (d) soluble interleukin-15 receptor alpha (IL-15Ra) polypeptide; wherein IL-15 domain of a first fusion protein binds to the soluble IL-15Ra domain of the second fusion protein to form a soluble fusion protein complex. | ||
| 地址 | Miramar FL US | ||