| 主权项 |
1. A compound of the Formula (I)or a pharmaceutically acceptable salt thereof,wherein:R1 is H or C1-C3 alkyl,R2 is H, halo, or C1-C3 alkyl;Ra and Rb are independently selected from the group consisting of H, C1-C6 alkyl, trifluoromethyl, and cyclopropyl,Z is —C(O)— or —SO2—;Rc is selected from the group consisting of
(a.) C1-C6 alkyl, wherein said C1-C6 alkyl of Rc is unsubstituted or independently substituted by 1 to 6 hydroxy, amino, oxo, C1-C3 alkylamino, C1-C3 alkoxy, C1-C3 dialkylamino or fluoro; (b.) C3-C9 mono- or bicycloalkyl, wherein said C3-C9 mono- or bicycloalkyl of Rc is unsubstituted or independently substituted by 1 to 4 C1-C3 alkyl, C1-C3 alkoxy, fluoro, trifluoromethyl, cyano, amino, C1-C3 alkylamino, or C1-C3 dialkylamino; (c.) a ring Cc of the formula wherein ring Cc is a 3- to 6-membered heterocyclyl, wherein said heterocyclyl is a saturated, partially saturated, or aromatic ring system containing 1 to 3 heteroatoms independently selected from the group consisting of N, O, and S, and is unsubstituted or independently substituted by 1 to 3 C1-C6 alkyl, C1-C3 alkoxy, fluoro, hydroxyl, oxo, cyano, amino, C1-C3 alkylamino, or C1-C3 dialkylamino; (d.) phenyl, wherein said phenyl of Rc is unsubstituted or independently substituted by 1 to 4 C1-C3 alkylsulfonyl;Rg is H or methyl;Rd is
(a.) C1-C8 alkyl, wherein said C1-C8 alkyl of Rd is unsubstituted or independently substituted by 1 to 6 halo, C1-C3 alkoxy, hydroxy, cyano, trimethylsilyl, or methylsulfonyl; (b.) C2-C8 alkenyl, wherein said C2-C8 alkenyl of Rd is unsubstituted or independently substituted by 1 to 6 fluoro or cyano; (c.) a group of the formula -M-RCH; M is
(i.) a bond; or(ii.) C1-C6 alkylene, wherein said C1-C6 alkylene of M is unsubstituted or substituted by 1 to 6 fluoro; RCH is a ring selected from the group consisting of
(i.) C3-C9 mono- or bicycloalkyl;(ii.) phenyl; and(iii.) a 3- to 6-membered heterocyclyl, wherein said heterocyclyl of RCH is a saturated or partially saturated ring system containing 1 to 2 heteroatoms independently selected from the group consisting of N, O, and S;wherein RCH is unsubstituted or independently substituted by 1 to 4 halo, C1-C3 alkyl, C1-C3 trifluoroalkyl, cyano, C1-C4 alkylcarbonylamino, or oxo;Cy is
(a.) phenyl; (b.) a 5- to 7-membered, monocyclic heterocyclyl, wherein said heterocyclyl of Cy is a saturated, partially saturated, or aromatic ring system containing 1 to 3 heteroatoms independently selected from the group consisting of N, O, and S; or (c.) C3-C6 cycloalkyl; wherein Cy is unsubstituted or independently substituted by 1 to 4 Rk moieties selected from the group consisting of:
(i.) C1-C6 alkyl, wherein said C1-C6 alkyl is unsubstituted or independently substituted by 1 to 3 hydroxy or fluoro;(ii.) C1-C6 alkoxy, wherein said C1-C6 alkoxy is unsubstituted or independently substituted by 1 to 3 fluoro, hydroxy, methoxy, or phenyl;(iii.) —N(Re)2;(iv.) —O(CH2)n1C(O)N(Re)2;(v.) —O(CH2)n2CO2Rf;(vi.) hydroxyl;(vii.) oxo;(viii.) halo;(ix.) C1-C3 alkylsulfonyl;(x.) cyano;(xi.) oxetanyl;(xii.) cyclopropyl;(xiii.) —(CH2)n1N(H)C(O)O—(C1-C6 alkyl); and(xiv.) —SF5; or alternatively, two Rk moieties, when substituted on adjacent ring atoms of Cy, form a second ring, wherein said second ring is a 5- to 7-membered saturated, partially saturated, or aromatic ring system containing 0, 1, or 2 heteroatoms independently selected from the group consisting of N, O, and S; wherein said second ring is unsubstituted or substituted by 1 to 3 Rk moieties independently selected from (i)-(xiv);each Re is independently H or C1-C3 alkyl,Rf is H or C1-C3 alkyl;the subscript n1 is 1, 2, or 3; andthe subscript n2 is 1, 2, or 3. |
