| 发明名称 |
Cyclosporin analogs |
| 摘要 |
Disclosed herein are novel analogs of cyclosporin, pharmaceutical compositions containing them, and methods for their use in the treatment of dry eye and other conditions. |
| 申请公布号 |
US9493511(B2) |
申请公布日期 |
2016.11.15 |
| 申请号 |
US201414534677 |
申请日期 |
2014.11.06 |
| 申请人 |
Allergan, Inc. |
发明人 |
Frydrych Catherine Simone Victoire;Carling William Robert;Garst Michael E.;Stern Michael E.;Schaumburg Christopher S. |
| 分类号 |
C07K7/64;C07K1/113;A61K38/00 |
主分类号 |
C07K7/64 |
| 代理机构 |
|
代理人 |
Potts Barbara C. |
| 主权项 |
1. A compound selected from the group consisting of:
[(S)-2-diethylaminoethylthiomethyl-Sar]3 cyclosporin A; [(S)-2-(4-pyridyl)ethylthiomethyl-Sar]3 cyclosporin A; [(S)-2-aminoethylthiomethyl-Sar]3 cyclosporin A; [(S)-2-dimethylaminoethylthiomethyl-Sar]3 cyclosporin A; [(S)-(4-methylpiperidinyl)thiomethyl-Sar]3 cyclosporin A; [(S)-2-(morpholino)ethylthiomethyl-Sar]3 cyclosporin A; and [(S)-2-isopropylaminoethylthiomethyl-Sar]3 cyclosporin A; and pharmaceutically acceptable salts of the foregoing compounds. |
| 地址 |
Irvine CA US |
