摘要 |
The invention relates to the use of a GABAA receptor agonist, such as an agonist or partial agonist of the 2 GABAA receptors and/or 3 GABAA receptors, for the preparation of a medicament for the prevention and treatment of neuropathic, inflammatory and migraine associated pain, and to a method of prevention and treatment of neuropathic, inflammatory and migraine associated pain using a GABAA receptor agonist. In particular, the invention relates to such a use, wherein the GABAA receptor agonist is an anxiolytic compound acting at the GABAA receptor benzodiazepine binding sites, and preferably having less binding affinity to 1 or less efficacy of receptor activation at 1 GABAA receptors compared to 2 and/or 3 GABAA receptors. Particular compounds considered are 1,2,4-triazolo[4,3-b]pyridazines, e.g. L-838,417, TPA 023 or CL-218,872, 1H- pyrido[3,4-b]indole derivatives, e.g. SL 651498, and pyrazolo[1,5-a]pyrimidines, e.g. ocinaplon. |