发明名称 |
INHIBITORS OF AKT/PKB WITH ANTI-TUMOR ACTIVITY |
摘要 |
The subject invention concerns materials and methods for inhibiting the Akt/PKB pathway. In one embodiment, a compound of the invention inhibits kinase activity and/or phosphorylation levels of Akt proteins. The subject invention also concerns methods for inhibiting or killing a cancer cell or other cell in which expression of an Akt protein is elevated or constitutively active, comprising contacting the cell with an effective amount of a compound of formula I. The subject invention also concerns methods for treating cancer or a tumor in a person or animal comprising administering all effective amount of a compound of formula I to the person or animal.
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申请公布号 |
US2009028855(A1) |
申请公布日期 |
2009.01.29 |
申请号 |
US20080172831 |
申请日期 |
2008.07.14 |
申请人 |
UNIVERSITY OF SOUTH FLORIDA |
发明人 |
CHENG JIN Q.;SUN MEI;SEBTI SAID M. |
分类号 |
A61K39/395;A61K31/519;A61P35/00;C07D471/04;C12N5/06 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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