| 发明名称 |
Antibiotic conjugates directly linked with steroid drugs |
| 摘要 |
The present invention describes novel single drug entities, formed by direct linkage of an antibiotic to a steroidal drug. Upon topical application to the eye, the conjugate would undergo enzymatic and/or hydrolytic cleavage to release the individual drugs. The antibiotic is coupled directly to the steroid drug. |
| 申请公布号 |
US9402912(B2) |
申请公布日期 |
2016.08.02 |
| 申请号 |
US201414198939 |
申请日期 |
2014.03.06 |
| 申请人 |
Allergan, Inc. |
发明人 |
Sinha Santosh C.;Chow Ken;Wang Liming;Garst Michael E.;Attar Mayssa;Swift Brandon D. |
| 分类号 |
C07D405/12;A61K47/48;A61K9/00;C07D215/56;C07D401/04;C07D471/04;C07D498/06 |
主分类号 |
C07D405/12 |
| 代理机构 |
|
代理人 |
Potts Barbara C. |
| 主权项 |
1. A hybrid drug comprising one antibiotic moiety and one steroid moiety, or a pharmaceutical salt thereof, which are connected covalently via a linker, wherein the bond is an ester bond or an amide bond, and wherein the antibiotic moiety is a gatifloxacin moiety and the steroid moiety is a prednisolone moiety. |
| 地址 |
Irvine CA US |
