| 发明名称 | Neuronal pain pathway modulators | ||
| 摘要 | The present invention relates to compounds that may be used to inhibit activation of protein kinase G (“PKG”). It is based, at least in part, on the discovery of the tertiary structure of PKG and the identification of molecules that either bind to the active site of PKG and/or are analogs of balanol. | ||
| 申请公布号 | US9402826(B2) | 申请公布日期 | 2016.08.02 |
| 申请号 | US201414500745 | 申请日期 | 2014.09.29 |
| 申请人 | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 发明人 | Ambron Richard;Sung Ying-Ju;Greenwood Jeremy;Frye Leah;Deng Shi-Xian;Xie Yuli;Landry Donald W. |
| 分类号 | A61K31/40;A61K31/335;A61K31/235 | 主分类号 | A61K31/40 |
| 代理机构 | Baker Botts L.L.P | 代理人 | Baker Botts L.L.P |
| 主权项 | 1. A pharmaceutical composition comprising a therapeutically effective amount of a compound represented by the following structure: where Z represents —NH; X represents Y represents R17 is phenyl, unsubstituted or substituted with one or more of hydroxyl, (C1-C4)alkoxy, alkoxylalkoxy, or halo; R18 together with R19 isand R20 is | ||
| 地址 | New York NY US | ||