ANTIGEN BINDING PROTEINS

摘要

The present invention relates to antigen binding proteins, such as antibodies, which bind to serum amyloid P component (SAP), polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. The present invention also concerns the use of such antigen binding proteins in the treatment or prophylaxis of diseases associated with amyloid deposition including systemic amyloidosis, local amyloidosis, Alzheimer's disease, and type 2 diabetes.

主权项

1. A method of treating a subject afflicted with a disease associated with amyloid deposition, which method comprises the step of administering to said subject a therapeutically effective amount of a serum amyloid P component (SAP) depleting compound and a humanised antibody, wherein the humanised antibody comprises SEQ ID NO:1 (CDRH1), SEQ ID NO:2 (CDRH2), SEQ ID NO:3 (CDRH3), SEQ ID NO:4 (CDRL1), SEQ ID NO:5 (CDRL2), and SEQ ID NO:6 (CDRL3), which binds to serum amyloid P component (SAP).