发明名称 |
PROCESS FOR THE SYNTHESIS OF A CXCR4 ANTAGONIST |
摘要 |
This invention relates to a process for synthesizing heterocyclic pharmaceutical compound which binds to the CXCR4 chemokine receptor. In one embodiment, the process comprises: a) reacting a 5,6,7,8-tetrahydroquinolinylamine and an alkyl aldehyde bearing a phthalimide or a di-tertiary-butoxycarbonyl (di-BOC) protecting group to form an imine; b) reducing the imine to form a secondary amine; c) reacting the secondary amine with a haloalkyl substituted heterocyclic compound, to form a phthalimido-protected or di-tert-butoxycarbonyl protected tertiary amine; and d) hydrolyzing the protected amine to obtain a compound having Formula I' |
申请公布号 |
EP1730113(B1) |
申请公布日期 |
2016.12.28 |
申请号 |
EP20050725450 |
申请日期 |
2005.03.11 |
申请人 |
Genzyme Corporation |
发明人 |
CRAWFORD, Jason, B.;CHEN, Gang;GAUTHIER, David;SKERLJ, Renato;BAIRD, Ian, R.;WILSON, Trevor, R. |
分类号 |
C07D215/38;A61K31/4709;C07D215/40;C07D401/12;C07D401/14 |
主分类号 |
C07D215/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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