| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for diagnosing or judging diathesis to breast cancer in a subject by determining the expression level of a BRC-associated gene in biological samples (tissue sample etc.) originated from a patient. SOLUTION: Objective methods for detecting and diagnosing breast cancer (BRC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates between BRC cells and normal cells. In another embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates among BRC cells, between DCIS and IDC cells. The present invention further provides means for predicting and preventing breast cancer metastasis using BRC-associated genes having unique altered expression patterns in breast cancer cells with lymph-node metastasis. Finally, the present invention provides methods of screening for therapeutic agents useful in the treatment of breast cancer, methods of treating breast cancer and method for vaccinating a subject against breast cancer. COPYRIGHT: (C)2008,JPO&INPIT
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