| 发明名称 |
Targeted Delivery of Factor VIII Proteins to Platelets |
| 摘要 |
The invention described herein relates to novel molecules and polypeptides comprising at least one amino acid sequence having significant identity with (homology to) human Factor VIII or biologically active portion(s) thereof, related molecules (such as nucleic acids encoding such polypeptides), compositions (such as pharmaceutical formulations) comprising such polypeptides, and methods of making and using such polypeptides. |
| 申请公布号 |
US2016251409(A1) |
申请公布日期 |
2016.09.01 |
| 申请号 |
US201615158796 |
申请日期 |
2016.05.19 |
| 申请人 |
Novo Nordisk A/S |
发明人 |
Oestergaard Henrik;Pusateri Anthony;Barnett Thomas R.;Buchardt Jens;Peschke Bernd;Kofod-Hansen Mikael;Zundel Magali A.;Behrens Carsten;Olsen Eva H. Norling;Stennicke Henning |
| 分类号 |
C07K14/755;C07K16/18 |
主分类号 |
C07K14/755 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A FVIII molecule comprising an amino acid sequence that is at least about 95% identical to the mature portion of an amino acid sequence selected from the group consisting of SEQ ID NO:1 and SEQ ID NO: 3, which FVIII molecule is covalently attached to a platelet-specific molecule, wherein said platelet-specific molecule is a non-inhibitory GPIIb/IIIa antibody. |
| 地址 |
Bagsvaerd DK |
