NON-CODING RNA OF SALMONELLA AND IDENTIFICATION AND USE THEREOF

摘要

The present invention provides Salmonella non-coding RNA and the identification and application thereof. In particular, the present invention proves through experiments that a Salmonella bacterium delivers non-coding RNAs (ncRNAs) encoded by the bacterium itself into a host cell, generates milRNAs similar to microRNAs by means of a microRNA splicing system in the cell, regulates the immune system with the milRNAs, and further protects the Salmonella bacterium from being cleared by the host. Adsorbing milRNAs using milRNA inhibitors can effectively inhibit the survival ability of the bacterium in the cell, leading to a reduced vitality of the bacterium. The present invention further provides relevant reagents and methods for effective detection of, treatment to and study on Salmonella bacteria or Salmonella infectious diseases.

主权项

1. An isolated micro-like RNA (milRNA), wherein the milRNA is selected from:
(i) milRNA whose sequence is shown in any of SEQ ID NOs: 1-5 and (ii) milRNA complementary to the nucleotide sequence of milRNA of (i).