摘要 |
The disclosure relates to compositions and methods for the treatment of fungal, bacterial, and parasitic infections and inhibition of fungal, bacterial, and parasitic growth. In particular, such compositions include dihydrofolate reductase (DHFR) inhibitors that are able to bind to DHFR and inhibit its function, resulting in inhibition of DNA biosynthesis and reduced cell division. The disclosure features DHFR inhibitors having a diaminoquinazoline scaffold. |
申请人 |
CIDARA THERAPEUTICS, INC. |
发明人 |
BALKOVEC, James, Michael;BENSEN, Daniel, C.;BORCHARDT, Allen;BRADY, Thomas, Patrick;CHEN, Zhi-yong;LAM, Thanh;TARI, Leslie, W. |