发明名称 |
Synthetic human neutralizing monoclonal antibodies to human immunodeficiency virus |
摘要 |
The present invention describes synthetic human monoclonal antibodies that immunoreact with and neutralize human immunodeficiency virus (HIV). The synthetic monoclonal antibodies of this invention exhibit enhanced binding affinity and neutralization ability to gp120. Also disclosed are immunotherapeutic and diagnostic methods of using the monoclonal antibodies, as well as cell lines for producing the monoclonal antibodies.
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申请公布号 |
US6395275(B1) |
申请公布日期 |
2002.05.28 |
申请号 |
US20000611451 |
申请日期 |
2000.07.06 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
BARBAS CARLOS F.;BURTON DENNIS R.;LERNER RICHARD A. |
分类号 |
G01N33/543;A61K39/395;A61K49/00;A61P31/18;C07K16/10;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12P21/08;C12R1/19;G01N33/569;G01N33/577;(IPC1-7):A61K39/42;G01N33/53 |
主分类号 |
G01N33/543 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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