| 摘要 |
<p>A compound of formula (I) wherein R1 is selected from the group consisting of phenyl substituted by one or more halogen atoms, naphthyl and naphthyl substituted by one or more halogen atoms; R2 is selected from the group consisting of -NH¿2? and -NHC(=O)R?a; R3¿ is selected from the group consisting of -NRbRc, -NHC(=O)Ra and hydrogen, R4 is selected from the group consisting of hydrogen, -C¿1-4? alkyl, -C1-4 alkyl substituted by one or more halogen atoms, -CN, -CH2OH, -CH2OR?d¿ and -CH¿2?S(O)x R?d¿; wherein Ra represents C¿1-4? alkyl or C3-7cycloalkyl, and R?b and Rc¿, which may be the same or different, are selected from hydrogen and C¿1-4? alkyl, or together with the nitrogen atom to which they are attached, form a 6-membered nitrogen containing heterocycle, which heterocycle can be further susbtituted with one or more C1-4 alkyl; R?d¿ is selected from C¿1-4? alkyl or C1-4 alkyl substituted by one or more halogen atoms; x is an integer zero, one or two; and pharmaceutically acceptable derivatives thereof; with the proviso that R?1¿ does not represent (a); when R2 is -NH¿2?, and both R?3 and R4¿ are hydrogen.</p> |
