TRIAZOLOQUINAZOLINE AND PYRAZOLOTRIAZOLOPYRIMIDINE DERIVATIVES, MEDICINAL COMPOSITIONS, ADENOSINE A3 RECEPTOR AFFINITY AGENTS, OCULAR TENSION LOWERING AGENTS, PREPARATIONS FOR PREVENTING AND TREATING GLAUCOMA AND METHOD OF LOWERING OCULAR TENSION

摘要

Triazoloquinazoline and pyrazolotriazolopyrimidine derivatives represented by the following general formula (1): (1) wherein R?1 and R2¿ are each as defined in the description; and A represents a pyrazole or benzene ring optionally substituted by the group as cited in the description. These derivatives show an affinity for adenosine A3 receptor and an effect of lowering ocular tension, which makes them useful in preventing or treating glaucoma.