发明名称 |
Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide |
摘要 |
An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.
|
申请公布号 |
US6476235(B2) |
申请公布日期 |
2002.11.05 |
申请号 |
US20010015558 |
申请日期 |
2001.12.17 |
申请人 |
|
发明人 |
|
分类号 |
A61K31/4025;C07B61/00;C07D207/34;C07D295/18;C07D295/185;C07D405/06;C07D413/04;(IPC1-7):C07D405/06 |
主分类号 |
A61K31/4025 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|