| 发明名称 | Salt form of a human histone methyltransferase EZH2 inhibitor | ||
| 摘要 | Provided herein is N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4′-(morpholinomethyl)-[1,1′-biphenyl]-3-carboxamide hydrobromide. Also provided herein is a particular polymorph form of this compound. | ||
| 申请公布号 | US9394283(B2) | 申请公布日期 | 2016.07.19 |
| 申请号 | US201314394431 | 申请日期 | 2013.04.11 |
| 申请人 | Epizyme, Inc.;Eisai R&D Management Co., LTD. | 发明人 | Kuntz Kevin Wayne;Huang Kuan-Chun;Choi Hyeong Wook;Sanders Kristen;Mathieu Steven;Chanda Arani;Fang Frances |
| 分类号 | C07D405/12 | 主分类号 | C07D405/12 |
| 代理机构 | Cooley LLP | 代理人 | Cooley LLP ;Erlacher Heidi A.;Ouyang Lian |
| 主权项 | 1. A polymorph of N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4′-(morpholinomethyl)-[1,1′-biphenyl]-3-carboxamide hydrobromide, wherein the polymorph exhibits an X-ray powder diffraction pattern having one or more characteristic peaks expressed in degrees 2-theta at about 3.9+/−0.3 degrees, about 17.5+/−0.3 degrees, and about 22.0+/−0.3 degrees 2-theta. | ||
| 地址 | Cambridge MA US | ||