Gene-Deleted Variant Strain Of Porcine Pseudorabies Virus, Vaccine Composition, Method Of Making The Same And Use Thereof

摘要

The present invention provides an attenuated strain of porcine pseudorabies virus (PRV), in which said attenuated strain of PRV is a variant strain of PRV with inactivation of gI/gE/11K/28K proteins. In addition, the present invention also provides a vaccine composition comprising the attenuated strain of PRV as an antigen, a preparation method and use thereof. Proved by immunogenicity and pathogenicity testing of the live vaccine, said live PRV vaccine can provide a good protection for pigs with no clinical signs observed, indicating excellent immune protection.

主权项

1. An attenuated strain of porcine pseudorabies virus comprising a first attenuated porcine pseudorabies virus strain, wherein the first attenuated strain of porcine pseudorabies comprises a porcine pseudorabies virus strain with inactivation of gI/gE/11K/28K protein.