ASEPTIC WET MILLING PROCESS FOR PALIPERIDONE PALMITATE

摘要

An aseptic wet milling process for preparing a pharmaceutical composition comprising micronized paliperidone palmitate by using two types of milling beads is disclosed. In particular, the aseptic wet milling process uses two types of milling beads sequentially in a single equipment to obtain particles of micronized paliperidone palmitate with desired size ranges and having uniform size distribution.