Methods and compositions for targeting polyubiquitin

摘要

Anti-polyubiquitin monoclonal antibodies, and methods for using the antibodies, are provided.

主权项

1. A nucleic acid molecule that encodes an antibody that specifically binds lysine-48-linked polyubiquitin, wherein the antibody comprises a hypervariable (HVR)-H1, a HVR-H2, a HVR-H3, a HVR-L1, a HVR-L2, and a HVR-L3, wherein the HVR-H1 sequence is selected from SEQ ID NOs: 265 to 280; wherein the HVR-H2 sequence is selected from SEQ ID NOs: 281 to 296; wherein the HVR-H3 sequence is selected from SEQ ID NOs: 297 to 312; wherein the HVR-L1 sequence is SEQ ID NO: 79; wherein the HVR-L2 sequence is SEQ ID NO: 80; and wherein the HVR-L3 sequence is selected from SEQ ID NOs: 313 to 328.