| 发明名称 | AAV mediated exendin-4 gene transfer to salivary glands to protect subjects from diabetes or obesity | ||
| 摘要 | The invention relates to a gene transfer-based method to protect a subject from diabetes or obesity. The method comprises administering to a salivary gland of the subject an AAV virion comprising an AAV vector that encodes an exendin-4 protein. Also provided are exendin-4 proteins and nucleic acid molecules that encode such exendin-4 proteins. Also provided are AAV vectors and AAV virions that encode an exendin-4 protein. One embodiment is an exendin-4 protein that is a fusion protein comprising an NGF secretory segment joined to the amino terminus of an exendin-4 protein domain. | ||
| 申请公布号 | US9511103(B2) | 申请公布日期 | 2016.12.06 |
| 申请号 | US201214112790 | 申请日期 | 2012.04.19 |
| 申请人 | The United States of America, as represented by the Secretary, Department of Health and Human Services | 发明人 | Chiorini John A.;Di Pasquale Giovanni;Mannucci Edoardo |
| 分类号 | A61K31/70;C12N15/00;A61K48/00;C07K14/00;C07H21/04;A61K35/761;C07K14/48;C07K14/575;C07K14/605;A61K38/17;C12N15/86 | 主分类号 | A61K31/70 |
| 代理机构 | Sheridan Ross P.C. | 代理人 | Sheridan Ross P.C. |
| 主权项 | 1. A method to protect a subject from Type II diabetes or obesity, the method comprising administering to a salivary gland of the subject an adeno-associated virus (AAV) virion comprising an AAV vector that encodes an exendin-4 fusion protein comprising a secretory segment joined to an exendin-4 protein. | ||
| 地址 | Washington DC US | ||