Orally disintegrating tablet

摘要

The present invention features a tablet containing at least one first material, at least one second material, and at least one pharmaceutically active agent, wherein:
(a) the first material is a dielectric water-containing material (i) containing from about 1 to about 5 percent, by weight, of bound water and (ii) having a dielectric loss, when measured at a density of between 0.15 and 0.5 g/cc, of from about 0.05 to about 0.7; and(b) the second material (i) having a water solubility from about 20 to about 400 g per 100 g of water at 25° C., (ii) having a dielectric loss, when measured at a density between 0.5 and 1 g/cc, of less than about 0.05.

主权项

1. A tablet comprising at least one first material, at least one second material, and at least one pharmaceutically active agent, wherein:
(a) said first material comprises maltodextrin; (b) said second material is a sugar or sugar alcohol; (c) said tablet comprises from at least 15% to about 45%, by weight, of said first material and from about 20% to about 64%, by weight, of said second material; (d) the combined weight of said at least one first material and said at least one second material comprises at least 60%, by weight, of said tablet; (e) said tablet has a friability of less than about 5%; (f) said tablet has a density less than about 0.8 g/cc; (g) said tablet disintegrates in the mouth when placed on the tongue in less than about 30 seconds; and (h) said tablet comprises less than 5%, by weight, of a polyethylene glycol.