Sustained-released product comprising a combination of a non-opioid amine and a non-steroidal, anti-inflammatory drug

摘要

Sustained-release oral pharmaceutical compositions and methods of use, wherein the compositions are in a single dosage form and include an amine-containing compound (including salts thereof), a salt of a non-steroidal anti-inflammatory drug (NSAID), and a hydrophilic matrix.

主权项

1. A sustained-release oral pharmaceutical composition comprising within a single dosage form:
a hydrophilic matrix comprising a cellulose ether selected from the group consisting of a hydroxyalkyl cellulose, a carboxyalkyl cellulose, and a combination thereof; a therapeutically effective amount of a non-opioid amine-containing compound; and a salt of a non-steroidal anti-inflammatory drug (NSAID); wherein the non-opioid amine-containing compound and the salt of an NSAID are within the hydrophilic matrix; and wherein the composition exhibits a release profile with respect to the non-opioid amine-containing compound, wherein the release profile comprises a substantial portion that is representative of zero-order release kinetics under in vitro conditions as a result of dissolution of the hydrophilic matrix.