| 发明名称 |
DNA mutagenesis by random fragmentation and reassembly for antibody production |
| 摘要 |
<p>The present invention provides a population of polynucleotides resulting from shuffling sequences from substrate polynucleotides encoding antibody chains, whereby the population of polynucleotides comprises recombinant polynucleotides encoding antibody chains having different combinations of heavy chain CDRs and/or light chain CDRs than are encoded by the substrate polynucleotides. Such a population of polynucleotides may be employed to provide an antibody display library.</p> |
| 申请公布号 |
EP1094108(A2) |
申请公布日期 |
2001.04.25 |
| 申请号 |
EP20010100962 |
申请日期 |
1995.02.17 |
| 申请人 |
MAXYGEN, INC. |
发明人 |
STEMMER, WILLEM P.C.;CRAMERI, ANDREAS |
| 分类号 |
C12N15/09;A61K38/00;A61K39/395;C07K14/435;C07K14/545;C07K16/00;C12N9/38;C12N9/86;C12N15/00;C12N15/10;C12P21/08;C12Q1/68;C40B40/02;G01N33/53;G01N33/566;(IPC1-7):C12N15/10 |
主分类号 |
C12N15/09 |
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