发明名称 |
Salts of aza-bicyclic di-aryl ethers and pharmaceuticals thereof |
摘要 |
The present invention relates to salts of (R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane, to methods for making them or their precursors, to pharmaceutical compositions comprising them, and to their use as medicaments. |
申请公布号 |
US9365565(B2) |
申请公布日期 |
2016.06.14 |
申请号 |
US201214232717 |
申请日期 |
2012.07.12 |
申请人 |
Novartis AG |
发明人 |
Marterer Wolfgang;Prashad Mahavir;Villhauer Edwin Bernard;Waykole Liladhar Murlidhar;Vivelo James Anthony;Sutter Bertrand;Bianchi Jean-Claude;Wu Raeann;Har Denis;Karpinski Piotr H.;Pignone Massimo;Stingelin Doris;Buerger Eckart |
分类号 |
A61K9/20;C07D453/02;A61K31/194;A61K31/439;C07C55/08;C07C55/10;C07C57/145;C07C57/15 |
主分类号 |
A61K9/20 |
代理机构 |
Hoffman Warnick LLC |
代理人 |
Hoffman Warnick LLC |
主权项 |
1. A pharmaceutical composition, which comprises
a salt of (R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane, wherein said salt is the fumarate, maleate, chloride, phosphate, succinate or malonate salt of (R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane as active ingredient; and at least one pharmaceutically acceptable carrier. |
地址 |
Basel CH |