Genetic test for liver copper accumulation in dogs and low copper pet diet

摘要

The present invention provides a method of testing a dog to determine the likelihood that the dog is protected from liver copper accumulation, comprising detecting in a sample the presence or absence in the genome of the dog of one or more polymorphisms selected from (a) SNP ATP7a_Reg3_F_6 (SEQ ID NO:142) and (b) one or more polymorphisms in linkage disequilibrium with (a).

主权项

1. A method of preventing a disease attributable to liver copper accumulation in dogs having genetic inheritance of the Labrador Retriever breed, comprising feeding a foodstuff comprising copper at a concentration of between 4.5 and 10 mg/kg dry matter to a dog having genetic inheritance of the Labrador Retriever breed directly determined to have at least one cytosine at position 102 of SEQ ID NO: 142.