摘要 |
Provided is a compound useful as an inhibitor against the kinase activity of EML4-ALK fusion protein. As a result of intensive and extensive studies on compounds having inhibitory activity against the kinase activity of EMLA-ALK fusion protein, the present inventors found that the diamino heterocyclic carboxamide compounds of the present invention had inhibitory activity against the kinase activity of EML4-ALK fusion protein. By this finding, the present invention was completed. The compounds of the present invention can be used as a pharmaceutical composition for preventing and/or treating cancer, such as lung cancer, non-small cell lung cancer, and small cell lung cancer. |
申请人 |
Astellas Pharma Inc.;Kotobuki Pharmaceutical Co., Ltd. |
发明人 |
SHIMADA, Itsuro;KUROSAWA, Kazuo;MATSUYA, Takahiro;IIKUBO, Kazuhiko;KONDOH, Yutaka;KAMIKAWA, Akio;TOMIYAMA, Hiroshi;IWAI, Yoshinori |