PHARMACEUTICAL COMPOSITION, METHOD OF PREPARATION AND METHODS OF TREATING ACHES/PAINS

摘要

Provided are methods and compositions useful for treating/aches and/or pains. The compositions include ibuprofen in a clear stable aqueous system of water, alcohol and glycerin that is stable at room temperature for at least 6 months without separation or precipitation. The composition is effective for delivering ibuprofen directly through the mucosal or buccal tissue without passing through the GI tract.

主权项

1. A stable water-soluble ibuprofen pharmaceutical composition which is stable for extended periods and through a wide variety of temperature extremes, effective for use as a sublingual spray comprising:
a solution of 0.1-200 mg/ml of ibuprofen USP grade powder, dissolved in an aqueous system of water, alcohol and glycerin; wherein said composition is stable without separation, precipitation or settling for at least 6 months; and wherein the particle size of said ibuprofen in said stable sublingual spray pharmaceutical composition is less than or equal to 500 nanometers.