SYNTHETIC POLYMERS AND METHODS OF MAKING AND USING THE SAME

摘要

Disclosed herein are monomer embodiments that can be used to make polymers, such as homopolymers, heteropolymers, and that can be used in particular embodiments to make sequence-defined polymers. Also disclosed herein are methods of making polymers using such monomer embodiments. Methods of using the polymers disclosed herein also are described.

主权项

1. A polymer having a formula: wherein when p is 1,
each T and Tf is a terminal group independently selected from hydrogen, heteroaliphatic, aliphatic, aryl, heteroaryl, aliphatic-aryl, aliphatic-heteroaryl, heteroaliphatic-aryl, or heteroaliphatic-heteroaryl;R1, each Rn, and Rf independently is selected from hydrogen, heteroaliphatic, aliphatic, aryl, heteroaryl, aliphatic-aryl, aliphatic-heteroaryl, heteroaliphatic-aryl, or heteroaliphatic-heteroaryl;Y1, each Yp, and Yf independently is selected from a bond, —C(R4)2—, oxygen, sulfur, or NR4, wherein each R4 independently is selected from hydrogen, aliphatic, heteroaliphatic, aryl, or heteroaryl and wherein R4 of NR4 and at least one of R1 or Rn are different;W1 and each Wa independently is selected from —C(R4)2, oxygen, sulfur, or NR4, wherein each R4 independently is selected from hydrogen, aliphatic, heteroaliphatic, aryl, or heteroaryl;Z1 and each Zb independently is selected from heteroaryl, oxygen, sulfur, or NR4, wherein R4 is selected from hydrogen, aliphatic, cyclic heteroaliphatic comprising one or more heteroatoms selected from oxygen, sulfur, selenium, phosphorous, or oxidized forms thereof, acyclic heteroaliphatic, heteroaryl, or aryl;L1 and each Lq independently is selected from aliphatic, heteroaliphatic, aryl, heteroaryl, carbosilane, silane, siloxane, polycarbosilane, polysilane, or polysiloxane;m ranges from 2 to 1000; and when p is 0,
each T and Tf is a terminal group independently selected from hydrogen, heteroaliphatic, aliphatic, aryl, heteroaryl, aliphatic-aryl, aliphatic-heteroaryl, heteroaliphatic-aryl, or heteroaliphatic-heteroaryl;at least one of R1, Rn, and Rf is hydrogen, and remaining R1, Rn, and Rf independently are selected from heteroaliphatic, aliphatic, aryl, heteroaryl, aliphatic-aryl, aliphatic-heteroaryl, heteroaliphatic-aryl, or heteroaliphatic-heteroaryl;at least one of Y1, Yp, and Yf independently is selected from a bond, oxygen, sulfur, or NR4, wherein R4 is hydrogen, and remaining Y1, Yp, and Yf are selected from a bond, —C(R4)2—, oxygen, sulfur, or NR4, wherein each R4 independently is selected from hydrogen, aliphatic, heteroaliphatic, aryl, or heteroaryl;W1 and each Wa independently is selected from —C(R4)2, oxygen, sulfur, or NR4, wherein each R4 independently is selected from hydrogen, aliphatic, heteroaliphatic, aryl, or heteroaryl;Z1 and each Zb independently is selected from heteroaryl, oxygen, sulfur, or NR4, wherein R4 is selected from hydrogen, aliphatic, heteroaliphatic, heteroaryl, or aryl;L1 and each Lq independently is selected from aliphatic, heteroaliphatic, aryl, heteroaryl, carbosilane, silane, siloxane, polycarbosilane, polysilane, or polysiloxane; andprovided that when p is 0
any one or more of R1 or Rn are not hydrogen if Y1 or Yp is NR4 where R4 is hydrogen and any one or more of L1 or Lq is phenyl; andany one or more of R1 or Rn are not hydrogen if Y1 or Yp is NR4 where R4 is hydrogen; any one or more of W1 or Wa is O; any one or more of L1 or Lq is —CH2—C(4-decyloxybenzyl)2-CH2—; and any one of Z1 or Zb is NH; andat least one of R1, Y1, W1, Z1, or L1 is different from at least one Rn, Yp, Wa, Zb, or Lq, respectively.