ANTIMICROBIAL CATIONIC POLYCARBONATES

摘要

Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end groups can comprise a covalently bound form of biologically active compound such as cholesterol. Other antimicrobial cationic polymers have a random copolycarbonate chain comprising a minor mole fraction of hydrophobic repeat units bearing a covalently bound form of a vitamin E and/or vitamin D2. The cationic polymers exhibit high activity and selectivity against Gram-negative and Gram-positive microbes and fungi.

主权项

1. An antimicrobial cationic polymer of formula (12):
Zc—Pb—C′—Pb—Zc  (12), wherein
C′ is a C2-C15 divalent linking group joining polymer chains Pb, wherein C′ comprises i) a first heteroatom linked to a first polymer chain Pb, wherein the first heteroatom is selected from the group consisting of nitrogen, oxygen, and sulfur, and ii) a second heteroatom linked to a second polymer chain Pb, wherein the second heteroatom is selected from the group consisting of nitrogen, oxygen, and sulfur,each Zc is an independent monovalent end group selected from the group consisting of hydrogen and C1-C15 moieties,each polymer chain Pb consists essentially of cationic carbonate repeat units, wherein i) the cationic polymer comprises a total of 5 to about 45 cationic carbonate repeat units, ii) each of the cationic carbonate repeat units comprises a) a backbone portion of the polymer chain comprising an aliphatic carbonate group, and b) a cationic side chain linked to the backbone portion, and iii) the cationic side chain comprises a positive-charged heteroatom Q′ of a quaternary ammonium group and/or quaternary phosphonium group,about 25% to 100% of all the cationic carbonate repeat units of the cationic polymer, designated first cationic carbonate repeat units, have a structure selected from the group consisting of and combinations thereof, wherein X− is a negative-charged ion, and
0% to about 75% of the cationic carbonate repeat units of the cationic polymer, designated second cationic carbonate repeat units, have a cationic side chain comprising 6 to 9 carbons.