Neurturin molecules

摘要

Neurturin polypeptides which possess reduced heparin and heparan sulfate binding affinity but retain neurotrophic activity, nucleic acids which encode the neurturin variants and vectors and host cells which express the enhanced neurturin polypeptides. Use of the enhanced neurturin polypeptides, nucleic acids and host cells in the treatment or prevention of disease.

主权项

1. A method of treating cellular degeneration or insufficiency comprising administering to a patient in need of such treatment a therapeutically effective amount of a neurturin polypeptide comprising the amino acid sequence shown in SEQ ID NO: 4;
wherein the neurturin polypeptide has a decreased affinity to heparin compared to the mature wild type neurturin (SEQ ID NO: 5).