HYDROXYALKYL STARCH DERIVATIVES AS REACTANTS FOR COUPLING TO THIOL GROUPS

摘要

The present invention relates to a hydroxyalkyl starch (HAS) derivative of formula (I) wherein F1 is a functional group comprising the group —NR′—, with R′ being H or alkyl; L is a spacer bridging F1 and S; wherein HAS′ is the remainder of the HAS molecule, Rb and Rc are —[(CR1R2)mO]n—H and are the same or different from each other; Ra is —[(CR1R2)mO]n—H with HAS′ being the remainder of the hydroxyalkyl starch molecule, or Ra is HAS″ with HAS′ and HAS″ together being the remainder of the hydroxyalkyl starch molecule; R1 and R2 are independently hydrogen or an alkyl group having from 1 to 4 carbon atoms, m is 2 to 4, wherein R1 and R2 are the same or different from each other in the m groups CR1R2; n is from 0 to 6.;